Phosphate Homeostasis - A Vital Metabolic Equilibrium Maintained Through the INPHORS Signaling Pathway.
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2020
- doi: 10.3389/fmicb.2020.01367
- issn: 1664-302X
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info:eu-repo/semantics/altIdentifier/doi/10.3389/fmicb.2020.01367
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info:eu-repo/semantics/altIdentifier/pmid/32765429
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info:eu-repo/semantics/altIdentifier/pissn/1664-302X
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info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_A37D3603EBB87
info:eu-repo/semantics/openAccess , CC BY 4.0 , https://creativecommons.org/licenses/by/4.0/
Mots-clés
PKA; SPX; Tor; acidocalcisome; inositol pyrophosphate; nutrient signaling; phosphate; polyphosphateSujets proches
Microscopic organisms Micro-organisms Germs MicrobesCiter ce document
S. Austin et al., « Phosphate Homeostasis - A Vital Metabolic Equilibrium Maintained Through the INPHORS Signaling Pathway. », Serveur académique Lausannois, ID : 10.3389/fmicb.2020.01367
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Cells face major changes in demand for and supply of inorganic phosphate (P i ). P i is often a limiting nutrient in the environment, particularly for plants and microorganisms. At the same time, the need for phosphate varies, establishing conflicts of goals. Cells experience strong peaks of P i demand, e.g., during the S-phase, when DNA, a highly abundant and phosphate-rich compound, is duplicated. While cells must satisfy these P i demands, they must safeguard themselves against an excess of P i in the cytosol. This is necessary because P i is a product of all nucleotide-hydrolyzing reactions. An accumulation of P i shifts the equilibria of these reactions and reduces the free energy that they can provide to drive endergonic metabolic reactions. Thus, while P i starvation may simply retard growth and division, an elevated cytosolic P i concentration is potentially dangerous for cells because it might stall metabolism. Accordingly, the consequences of perturbed cellular P i homeostasis are severe. In eukaryotes, they range from lethality in microorganisms such as yeast (Sethuraman et al., 2001; Hürlimann, 2009), severe growth retardation and dwarfism in plants (Puga et al., 2014; Liu et al., 2015; Wild et al., 2016) to neurodegeneration or renal Fanconi syndrome in humans (Legati et al., 2015; Ansermet et al., 2017). Intracellular P i homeostasis is thus not only a fundamental topic of cell biology but also of growing interest for medicine and agriculture.