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2013
- doi: 10.3389/fncel.2013.00228
- issn: 1662-5102
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info:eu-repo/semantics/altIdentifier/pmid/24324401
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info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_90713ED33BE83
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Animals--Physiology Animal physiology Neurocytes Nerve cells Glial cells Peripheral neuropathies Peripheral nerves Nervous system, Peripheral Peripheral nervous system Mouse House mice Mus musculus House mouse World literature Western literature (Western countries) Belles-lettres Analysis (Mathematics) Cross talk Communication, Primitive Mass communication Methods of analysis Analysis and chemistry Analytical methods Chemical analysis Analysis methods Analysis and examinationCiter ce document
C. Samara et al., « Neuronal activity in the hub of extrasynaptic Schwann cell-axon interactions. », Serveur académique Lausannois, ID : 10.3389/fncel.2013.00228
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The integrity and function of neurons depend on their continuous interactions with glial cells. In the peripheral nervous system glial functions are exerted by Schwann cells (SCs). SCs sense synaptic and extrasynaptic manifestations of action potential propagation and adapt their physiology to support neuronal activity. We review here existing literature data on extrasynaptic bidirectional axon-SC communication, focusing particularly on neuronal activity implications. To shed light on underlying mechanisms, we conduct a thorough analysis of microarray data from SC-rich mouse sciatic nerve at different developmental stages and in neuropathic models. We identify molecules that are potentially involved in SC detection of neuronal activity signals inducing subsequent glial responses. We further suggest that alterations in the activity-dependent axon-SC crosstalk impact on peripheral neuropathies. Together with previously reported data, these observations open new perspectives for deciphering glial mechanisms of neuronal function support.