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2 mars 2022
- doi: 10.3390/cells11050867
- issn: 2073-4409
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info:eu-repo/semantics/altIdentifier/doi/10.3390/cells11050867
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info:eu-repo/semantics/altIdentifier/pmid/35269489
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info:eu-repo/semantics/altIdentifier/eissn/2073-4409
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info:eu-repo/grantAgreement/SNF/Projects/CRSII5_202276///
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info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_98080A5141E08
info:eu-repo/semantics/openAccess , CC BY 4.0 , https://creativecommons.org/licenses/by/4.0/
Mots-clés
animal models; cardiomyocyte; heart failure with preserved left ventricular ejection fractionSujets proches
Cardiac failure Failure, Heart Insufficiency, Cardiac Cardiac insufficiency UnderstandingCiter ce document
A. Rocca et al., « The Cardiomyocyte in Heart Failure with Preserved Ejection Fraction-Victim of Its Environment? », Serveur académique Lausannois, ID : 10.3390/cells11050867
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Heart failure (HF) with preserved left ventricular ejection fraction (HFpEF) is becoming the predominant form of HF. However, medical therapy that improves cardiovascular outcome in HF patients with almost normal and normal systolic left ventricular function, but diastolic dysfunction is missing. The cause of this unmet need is incomplete understanding of HFpEF pathophysiology, the heterogeneity of the patient population, and poor matching of therapeutic mechanisms and primary pathophysiological processes. Recently, animal models improved understanding of the pathophysiological role of highly prevalent and often concomitantly presenting comorbidity in HFpEF patients. Evidence from these animal models provide first insight into cellular pathophysiology not considered so far in HFpEF disease, promising that improved understanding may provide new therapeutical targets. This review merges observation from animal models and human HFpEF disease with the intention to converge cardiomyocytes pathophysiological aspects and clinical knowledge.