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3 février 2023
- doi: 10.3390/diagnostics13030564
- issn: 2075-4418
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info:eu-repo/semantics/altIdentifier/pmid/36766670
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Diseases--ImagingCiter ce document
A. Rizzo et al., « Potential Role of PSMA-Targeted PET in Thyroid Malignant Disease: A Systematic Review. », Serveur académique Lausannois, ID : 10.3390/diagnostics13030564
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Résumé
Recently, several studies introduced the potential use of positron emission tomography/computed tomography (PET/CT) with prostate-specific membrane antigen (PSMA)-targeting radiopharmaceuticals in radioiodine-refractory thyroid cancer (TC). The authors accomplished a comprehensive literature search of original articles concerning the performance of PSMA-targeted PET/CT in TC patients. Original papers exploring this molecular imaging examination in radioiodine-refractory TC patients undergoing restaging of their disease were included. A total of 6 documents concerning the diagnostic performance of PSMA-targeted PET/CT in TC (49 patients) were included in this systematic review. The included articles reported heterogeneous values of PSMA-targeted PET/CT detection rates in TC, ranging from 25% to 100% and overall inferior to [ 18 F]-fluorodeoxyglucose PET/CT when the two molecular imaging examinations were compared. Two studies reported the administration of [ 177 Lu]PSMA-radioligands with theragnostic purpose in three patients. The available literature data in this setting are limited and heterogeneous. The employment of PET with PSMA-targeting radiopharmaceuticals in this setting did not affect patient management. Nevertheless, prospective multicentric studies are needed to properly assess its potential role in TC patients.