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24 février 2021
- doi: 10.3390/jcm10050894
- issn: 2077-0383
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info:eu-repo/semantics/altIdentifier/doi/10.3390/jcm10050894
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info:eu-repo/semantics/altIdentifier/pmid/33668091
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info:eu-repo/semantics/altIdentifier/pissn/2077-0383
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info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_9F90D1DF5B610
info:eu-repo/semantics/openAccess , CC BY 4.0 , https://creativecommons.org/licenses/by/4.0/
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Thrombocytes PlateletsCiter ce document
A. Aliotta et al., « Thrombocytopathies: Not Just Aggregation Defects-The Clinical Relevance of Procoagulant Platelets. », Serveur académique Lausannois, ID : 10.3390/jcm10050894
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Platelets are active key players in haemostasis. Qualitative platelet dysfunctions result in thrombocytopathies variously characterized by defects of their adhesive and procoagulant activation endpoints. In this review, we summarize the traditional platelet defects in adhesion, secretion, and aggregation. In addition, we review the current knowledge about procoagulant platelets, focusing on their role in bleeding or thrombotic pathologies and their pharmaceutical modulation. Procoagulant activity is an important feature of platelet activation, which should be specifically evaluated during the investigation of a suspected thrombocytopathy.