Effects of Dietary Protein and Fat Content on Intrahepatocellular and Intramyocellular Lipids during a 6-Day Hypercaloric, High Sucrose Diet: A Randomized Controlled Trial in Normal Weight Healthy Subjects.

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21 janvier 2019

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Serveur académique Lausannois

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Ce document est lié à :
info:eu-repo/semantics/altIdentifier/doi/10.3390/nu11010209

Ce document est lié à :
info:eu-repo/semantics/altIdentifier/pmid/30669704

Ce document est lié à :
info:eu-repo/semantics/altIdentifier/eissn/2072-6643

Ce document est lié à :
info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_C97FC4EB08599

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Serveur Académique Lausannois

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Université de Lausanne et CHUV

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info:eu-repo/semantics/openAccess , CC BY 4.0 , https://creativecommons.org/licenses/by/4.0/

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Adipose Tissue/metabolism; Adiposity/drug effects; Adult; Cross-Over Studies; Diet; Diet, High-Fat/adverse effects; Diet, Protein-Restricted/adverse effects; Dietary Fats/administration & dosage; Dietary Fats/metabolism; Dietary Fats/pharmacology; Dietary Proteins/administration & dosage; Dietary Proteins/pharmacology; Dietary Sucrose/adverse effects; Energy Intake; Feeding Behavior; Female; Healthy Volunteers; Humans; Lipid Metabolism/drug effects; Lipids; Liver/cytology; Liver/drug effects; Liver/metabolism; Male; Muscle, Skeletal/cytology; Muscle, Skeletal/drug effects; Muscle, Skeletal/metabolism; Young Adult; dietary fat content; dietary protein content; energy expenditure; hepatic steatosis; intrahepatocellular lipids; intramyocellular lipids; plasma triglyceride; sucrose overfeeding

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diet

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A. Surowska et al., « Effects of Dietary Protein and Fat Content on Intrahepatocellular and Intramyocellular Lipids during a 6-Day Hypercaloric, High Sucrose Diet: A Randomized Controlled Trial in Normal Weight Healthy Subjects. », Serveur académique Lausannois, ID : 10.3390/nu11010209

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Sucrose overfeeding increases intrahepatocellular (IHCL) and intramyocellular (IMCL) lipid concentrations in healthy subjects. We hypothesized that these effects would be modulated by diet protein/fat content. Twelve healthy men and women were studied on two occasions in a randomized, cross-over trial. On each occasion, they received a 3-day 12% protein weight maintenance diet (WM) followed by a 6-day hypercaloric high sucrose diet (150% energy requirements). On one occasion the hypercaloric diet contained 5% protein and 25% fat (low protein-high fat, LP-HF), on the other occasion it contained 20% protein and 10% fat (high protein-low fat, HP-LF). IHCL and IMCL concentrations (magnetic resonance spectroscopy) and energy expenditure (indirect calorimetry) were measured after WM, and again after HP-LF/LP-HF. IHCL increased from 25.0 ± 3.6 after WM to 147.1 ± 26.9 mmol/kg wet weight (ww) after LP-HF and from 30.3 ± 7.7 to 57.8 ± 14.8 after HP-LF (two-way ANOVA with interaction: p < 0.001 overfeeding x protein/fat content). IMCL increased from 7.1 ± 0.6 to 8.8 ± 0.7 mmol/kg ww after LP-HF and from 6.2 ± 0.6 to 6.9 ± 0.6 after HP-LF, (p < 0.002). These results indicate that liver and muscle fat deposition is enhanced when sucrose overfeeding is associated with a low protein, high fat diet compared to a high protein, low fat diet.

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