Fiche du document
5 juin 2019
- doi: 10.3390/nu11061282
- issn: 2072-6643
Ce document est lié à :
info:eu-repo/semantics/altIdentifier/doi/10.3390/nu11061282
Ce document est lié à :
info:eu-repo/semantics/altIdentifier/pmid/31195757
Ce document est lié à :
info:eu-repo/semantics/altIdentifier/eissn/2072-6643
Ce document est lié à :
info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_AA82CE3BA2B83
info:eu-repo/semantics/openAccess , CC BY 4.0 , https://creativecommons.org/licenses/by/4.0/
Sujets proches
HMOs Prepaid medical care Medical care, Prepaid Health plans, Prepaid Comprehensive health care delivery organizations Prepaid health plans Health care delivery organizations, Comprehensive Prepaid group medical practiceCiter ce document
S. Austin et al., « Human Milk Oligosaccharides in the Milk of Mothers Delivering Term versus Preterm Infants. », Serveur académique Lausannois, ID : 10.3390/nu11061282
Métriques
Partage / Export
Résumé
Human milk oligosaccharides (HMOs) are a major component of human milk, and play an important role in protecting the infant from infections. Preterm infants are particularly vulnerable, but have improved outcomes if fed with human milk. This study aimed to determine if the HMO composition of preterm milk differed from that of term milk at equivalent stage of lactation and equivalent postmenstrual age. In all, 22 HMOs were analyzed in 500 samples of milk from 25 mothers breastfeeding very preterm infants (< 32 weeks of gestational age, < 1500g of birthweight) and 28 mothers breastfeeding term infants. The concentrations of most HMOs were comparable at equivalent postpartum age. However, HMOs containing α-1,2-linked fucose were reduced in concentration in preterm milk during the first month of lactation. The concentrations of a number of sialylated oligosaccharides were also different in preterm milk, in particular 3'-sialyllactose concentrations were elevated. At equivalent postmenstrual age, the concentrations of a number of HMOs were significantly different in preterm compared to term milk. The largest differences manifest around 40 weeks of postmenstrual age, when the milk of term infants contains the highest concentrations of HMOs. The observed differences warrant further investigation in view of their potential clinical impact.