Urinary metabolic insights into host-gut microbial interactions in healthy and IBD children.

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Date

28 mai 2017

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Source

Serveur académique Lausannois

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Ce document est lié à :
info:eu-repo/semantics/altIdentifier/doi/10.3748/wjg.v23.i20.3643

Ce document est lié à :
info:eu-repo/semantics/altIdentifier/pmid/28611517

Ce document est lié à :
info:eu-repo/semantics/altIdentifier/eissn/2219-2840

Ce document est lié à :
info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_251A4C223CEF3

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Serveur Académique Lausannois

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Université de Lausanne et CHUV

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info:eu-repo/semantics/openAccess , Copying allowed only for non-profit organizations , https://serval.unil.ch/disclaimer

Mots-clés 0

Adolescent; Anthropometry; Bile Acids and Salts/urine; Body Composition; Case-Control Studies; Child; Colitis, Ulcerative/urine; Crohn Disease/urine; Cysteine/urine; Female; Gas Chromatography-Mass Spectrometry; Gastrointestinal Microbiome; Glutamic Acid/urine; Glutathione/urine; Glycine/urine; Humans; Inflammation; Inflammatory Bowel Diseases/microbiology; Inflammatory Bowel Diseases/urine; Male; Metabolome; Metabolomics; Microbial Interactions; Phenotype; Pyrrolidonecarboxylic Acid/urine; Signal Transduction; Urine/chemistry; Crohn’s disease; Growth; Inflammatory bowel disease; Metabolism; Pediatric; Ulcerative colitis

Sujets proches En

Childhood Youngsters Pedology (Child study) Kids (Children)

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F.P. Martin et al., « Urinary metabolic insights into host-gut microbial interactions in healthy and IBD children. », Serveur académique Lausannois, ID : 10.3748/wjg.v23.i20.3643

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To identify metabolic signatures in urine samples from healthy and inflammatory bowel disease (IBD) children. We applied liquid chromatography and gas chromatography coupled to targeted mass spectrometry (MS)-based metabolite profiling to identify and quantify bile acids and host-gut microbial metabolites in urine samples collected from 21 pediatric IBD patients monitored three times over one year (baseline, 6 and 12 mo), and 27 age- and gender-matched healthy children. urinary metabolic profiles of IBD children differ significantly from healthy controls. Such metabolic differences encompass central energy metabolism, amino acids, bile acids and gut microbial metabolites. In particular, levels of pyroglutamic acid, glutamic acid, glycine and cysteine, were significantly higher in IBD children in the course of the study. This suggests that glutathione cannot be optimally synthesized and replenished. Whilst alterations of the enterohepatic circulation of bile acids in pediatric IBD patients is known, we show here that non-invasive urinary bile acid profiling can assess those altered hepatic and intestinal barrier dysfunctions. The present study shows how non-invasive sampling of urine followed by targeted MS-based metabonomic analysis can elucidate and monitor the metabolic status of children with different GI health/disease status.

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