High participation rate among 25 721 patients with broad age range in a hospital-based research project involving whole-genome sequencing - the Lausanne Institutional Biobank.

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Auteurs
Date

2017

Type de document
Périmètre
Langue
Identifiants
Source

Serveur académique Lausannois

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Ce document est lié à :
info:eu-repo/semantics/altIdentifier/doi/10.4414/smw.2017.14528

Ce document est lié à :
info:eu-repo/semantics/altIdentifier/pmid/29063527

Ce document est lié à :
info:eu-repo/semantics/altIdentifier/eissn/1424-3997

Ce document est lié à :
info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_4F0737C490445

Collection

Serveur Académique Lausannois

Organisation

Université de Lausanne et CHUV

Licences

info:eu-repo/semantics/openAccess , Copying allowed only for non-profit organizations , https://serval.unil.ch/disclaimer

Mots-clés 0

Age Factors; Biological Specimen Banks/organization & administration; Biomedical Research/organization & administration; Cross-Sectional Studies; Female; Genomics; Hospitals/statistics & numerical data; Humans; Incidental Findings; Male; Middle Aged; Patient Selection; Research Design; Sex Factors; Switzerland; Whole Genome Sequencing

Sujets proches En

Older persons Older adults Seniors (Older people) Elderly people Old people Senior citizens Aging people Aged

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M. Bochud et al., « High participation rate among 25 721 patients with broad age range in a hospital-based research project involving whole-genome sequencing - the Lausanne Institutional Biobank. », Serveur académique Lausannois, ID : 10.4414/smw.2017.14528

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We aimed to evaluate the interest of adult inpatients and selected outpatients in engaging in a large, real-life, hospital-based, genomic medicine research project and in receiving clinically actionable incidental findings. Within the framework of the cross-sectional Institutional Biobank of Lausanne, Switzerland, a total of 25721 patients of the CHUV University Hospital were systematically invited to grant researchers access to their biomedical data and to donate blood for future analyses, including whole-genome sequencing. Multivariable logistic regression analysis was used to identify personal factors, including age, gender, religion, ethnicity, citizenship, education level and mode of admission, associated with willingness to participate in this genomic research project and with interest in receiving clinically actionable incidental findings. The overall participation rate was 79% (20343/25721). Participation rate declined progressively with age, averaging 83%, 75%, 67% and 62% in patients aged

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