Allergologie-immunologie - Maladies autoimmunes complexes : quand les glucocorticoïdes ne suffisent plus [Difficult to treat auto-immune diseases : when glucocorticoids are not enough]
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19 janvier 2022
- doi: 10.53738/REVMED.2022.18.764-65.15
- issn: 1660-9379
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info:eu-repo/semantics/altIdentifier/pmid/35048572
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info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_AECB3687D9426
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Therapy Diseases and hygiene Sickness Human beings--Diseases Morbidity Illness Sicknesses IllnessesCiter ce document
J. Dereme et al., « Allergologie-immunologie - Maladies autoimmunes complexes : quand les glucocorticoïdes ne suffisent plus [Difficult to treat auto-immune diseases : when glucocorticoids are not enough] », Serveur académique Lausannois, ID : 10.53738/REVMED.2022.18.764-65.15
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Glucocorticosteroids (GC) remain the mainstay of treatment in most systemic inflammatory diseases. GC have a broad anti-inflammatory action of rapid onset. The downsides of prolonged GC therapy are well established and include infections, osteoporosis and metabolic adverse effects, among others. In systemic sclerosis, GC are associated with an increased risk of scleroderma renal crisis and must be avoided. Adjunction of second-line immunosuppressive drugs may improve disease control and limit GC usage. We summarize here the findings of two studies published in 2021, one reporting the benefits of combining GC with mycophenolate mofetil in immune thrombocytopenia, the other suggesting that blockage of interleukin-6 may decrease disease progression in systemic sclerosis with lung involvement.