Médecine de précision dans le traitement des cancers pédiatriques [Precision medicine in the treatment of pediatric cancers]
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22 février 2023
- doi: 10.53738/REVMED.2023.19.815.380
- issn: 1660-9379
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Cancers Néoplasme malin Tumeurs malignesCiter ce document
K. Ben Hassine et al., « Médecine de précision dans le traitement des cancers pédiatriques [Precision medicine in the treatment of pediatric cancers] », Serveur académique Lausannois, ID : 10.53738/REVMED.2023.19.815.380
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Despite the progress in cure rates for pediatric cancers, several challenges remain, such as the management of diseases with poor prognosis. The efficacy of intensified chemotherapies is also accompanied by increased risks of severe acute and chronic toxicities. Thus, therapies specifically targeting tumor cells, or inhibiting oncogenic molecular aberrations, could provide more effective and less toxic treatments for pediatric cancers. Personalization of chemotherapies through pharmacogenetics and precision dosing could also improve the efficacy and toxicity of chemotherapies. In this review, we describe precision medicine strategies implemented or undergoing clinical evaluation in the treatment of pediatric cancers.