Prospective study evaluating a diagnostic strategy for giant cell arteritis based on temporal artery color Doppler ultrasound with a 2-year follow-up: ECHORTON study
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4 avril 2023
- doi: 10.57745/AUMB8X
Mots-clés
Medicine, Health and Life Sciences Giant Cell Arteritis Diagnostic Tests, Routine Ultrasonography, Doppler, Color Temporal Arteries BiopsySujets proches
Arteritis, Giant cell Arteritis, Temporal Cranial arteritis Arteritis, Cranial Horton's arteritis Temporal arteritisCiter ce document
Guillaume Denis et al., « Prospective study evaluating a diagnostic strategy for giant cell arteritis based on temporal artery color Doppler ultrasound with a 2-year follow-up: ECHORTON study », Recherche Data Gouv, ID : 10.57745/AUMB8X
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Résumé
The purpose of the data collection was to assess the safety and accuracy of a diagnostic algorithm for giant cell arteritis based on color Doppler ultrasound of temporal arteries as a first-line examination. Demographic, clinical, biological, imaging and pathological data were collected. Giant Cell arteritis (GCA) is the most prevalent systemic vasculitis in people aged over 50. Any delay in diagnosis impairs patients' quality of life and can lead to permanent damage, particularly to their vision. In this prospective multicenter diagnostic accuracy study with the physician expertise as the reference method and a 2-year follow-up, 165 patients over 50 years of age with suspected GCA were enrolled. CDU was performed less than seven days after initiation of corticosteroid therapy. Only CDU-negative patients underwent TAB within seven days of CDU. Bilateral temporal halo signs were considered CDU-positive. Physicians diagnosed GCA based on clinical findings, imaging and response to corticosteroids. CDU was positive in 44% (73/165) of the patients. The sensitivity and specificity of CDU were 54% [95% CI 45-62] and 100% [95% CI 86-100] respectively. Bilateral temporal halo sign was a reliable diagnostic sign for confirming giant cell arteritis in cases of intermediate or high clinical suspicion.