Fiche du document
5 septembre 2017
- doi: 10.7554/eLife.30697
- issn: 2050-084X
Ce document est lié à :
info:eu-repo/semantics/altIdentifier/doi/10.7554/eLife.30697
Ce document est lié à :
info:eu-repo/semantics/altIdentifier/pmid/28871962
Ce document est lié à :
info:eu-repo/semantics/altIdentifier/eissn/2050-084X
Ce document est lié à :
info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_C0F4A680320F7
info:eu-repo/semantics/openAccess , Copying allowed only for non-profit organizations , https://serval.unil.ch/disclaimer
Sujets proches
Mouse House mice Mus musculus House mouse MidbrainCiter ce document
S. Lecca et al., « Aversive stimuli drive hypothalamus-to-habenula excitation to promote escape behavior. », Serveur académique Lausannois, ID : 10.7554/eLife.30697
Métriques
Partage / Export
Résumé
A sudden aversive event produces escape behaviors, an innate response essential for survival in virtually all-animal species. Nuclei including the lateral habenula (LHb), the lateral hypothalamus (LH), and the midbrain are not only reciprocally connected, but also respond to negative events contributing to goal-directed behaviors. However, whether aversion encoding requires these neural circuits to ultimately prompt escape behaviors remains unclear. We observe that aversive stimuli, including foot-shocks, excite LHb neurons and promote escape behaviors in mice. The foot-shock-driven excitation within the LHb requires glutamatergic signaling from the LH, but not from the midbrain. This hypothalamic excitatory projection predominates over LHb neurons monosynaptically innervating aversion-encoding midbrain GABA cells. Finally, the selective chemogenetic silencing of the LH-to-LHb pathway impairs aversion-driven escape behaviors. These findings unveil a habenular neurocircuitry devoted to encode external threats and the consequent escape; a process that, if disrupted, may compromise the animal's survival.