25 décembre 2018
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info:eu-repo/semantics/altIdentifier/doi/10.7554/eLife.39111
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info:eu-repo/semantics/altIdentifier/pmid/30583750
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info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_872EE93FB4BC0
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L.M. Fernandez et al., « Thalamic reticular control of local sleep in mouse sensory cortex. », Serveur académique Lausannois, ID : 10.7554/eLife.39111
Sleep affects brain activity globally, but many cortical sleep waves are spatially confined. Local rhythms serve cortical area-specific sleep needs and functions; however, mechanisms controlling locality are unclear. We identify the thalamic reticular nucleus (TRN) as a source for local, sensory-cortex-specific non-rapid-eye-movement sleep (NREMS) in mouse. Neurons in optogenetically identified sensory TRN sectors showed stronger repetitive burst discharge compared to non-sensory TRN cells due to higher activity of the low-threshold Ca 2+ channel Ca V 3.3. Major NREMS rhythms in sensory but not non-sensory cortical areas were regulated in a Ca V 3.3-dependent manner. In particular, NREMS in somatosensory cortex was enriched in fast spindles, but switched to delta wave-dominated sleep when Ca V 3.3 channels were genetically eliminated or somatosensory TRN cells chemogenetically hyperpolarized. Our data indicate a previously unrecognized heterogeneity in a powerful forebrain oscillator that contributes to sensory-cortex-specific and dually regulated NREMS, enabling local sleep regulation according to use- and experience-dependence.