2023
Cairn
Gilles Macaigne, « Colites microscopiques d’origine médicamenteuse », Hépato-Gastro & Oncologie Digestive, ID : 10670/1.084izk
Microscopic colitis (MC), collagenous (CC) and lymphocytic colitis (LC), the cause of chronic secretory diarrhea, is very likely secondary to an inappropriate immune response to an intraluminal antigen occurring in a genetically predisposed subject. The origin of this immune dysfunction is currently unknown but various triggering or promoting factors such as drugs have been widely discussed. The 3 main therapeutic classes associated with the occurrence of MC in many cohort or case-control studies are proton pump inhibitors, nonsteroidal anti-inflammatory drugs and selective serotonin reuptake inhibitors. Other drugs, implicated in clinical cases directly reporting a causal link between the drug and CM, were analyzed using the algorithm developed by Beaugerie et al. and the imputability of each drug was evaluated. The initial management of a CM imposes to eliminate an associated celiac disease and a drug cause. Any drug started in the 4 months preceding the onset of diarrhea should be suspected, its withdrawal leading to clinical improvement in a few days and the disappearance of histological lesions in a few weeks.