Classification of current anticancer immunotherapies.

L. Galluzzi; E. Vacchelli; J.M. Bravo-San Pedro; A. Buqué; L. Senovilla; E.E. Baracco; N. Bloy; F. Castoldi; J.P. Abastado; P. Agostinis; R.N. Apte; F. Aranda; M. Ayyoub; P. Beckhove; J.Y. Blay; L. Bracci; A. Caignard; C. Castelli; F. Cavallo; E. Celis; V. Cerundolo; A. Clayton; M.P. Colombo; L. Coussens; M.V. Dhodapkar; A.M. Eggermont; D.T. Fearon; W.H. Fridman; J. Fučíková; D.I. Gabrilovich; J. Galon; A. Garg; F. Ghiringhelli; G. Giaccone; E. Gilboa; S. Gnjatic; A. Hoos; A. Hosmalin; D. Jäger; P. Kalinski; K. Kärre; O. Kepp; R. Kiessling; J.M. Kirkwood; E. Klein; A. Knuth; C.E. Lewis; R. Liblau; M.T. Lotze; E. Lugli; J.P. Mach; F. Mattei; D. Mavilio; I. Melero; C.J. Melief; E.A. Mittendorf; L. Moretta; A. Odunsi; H. Okada; A.K. Palucka; M.E. Peter; K.J. Pienta; A. Porgador; G.C. Prendergast; G.A. Rabinovich; N.P. Restifo; N. Rizvi; C. Sautès-Fridman; H. Schreiber; B. Seliger; H. Shiku; B. Silva-Santos; M.J. Smyth; D.E. Speiser; R. Spisek; P.K. Srivastava; J.E. Talmadge; E. Tartour; S.H. Van Der Burg; B.J. Van Den Eynde; R. Vile; H. Wagner; J.S. Weber; T.L. Whiteside; J.D. Wolchok; L. Zitvogel; W. Zou; G. Kroemer

Classification of current anticancer immunotherapies.

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Date

2014

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Périmètre

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Anglais

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handle: 10670/1.0bmryb
issn: 1949-2553

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Serveur académique Lausannois

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Ce document est lié à :
info:eu-repo/semantics/altIdentifier/pmid/25537519

Ce document est lié à :
info:eu-repo/semantics/altIdentifier/eissn/1949-2553

Ce document est lié à :
info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_D59B3440A2048

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Serveur Académique Lausannois

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Université de Lausanne et CHUV

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info:eu-repo/semantics/openAccess , Copying allowed only for non-profit organizations , https://serval.unil.ch/disclaimer

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adoptive cell transfer; checkpoint blockers; dendritic cell-based interventions; DNA-based vaccines; immunostimulatory cytokines; peptide-based vaccines; oncolytic viruses; Toll-like receptor agonists

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Knowledge, Classification of

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L. Galluzzi et al., « Classification of current anticancer immunotherapies. », Serveur académique Lausannois, ID : 10670/1.0bmryb

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During the past decades, anticancer immunotherapy has evolved from a promising therapeutic option to a robust clinical reality. Many immunotherapeutic regimens are now approved by the US Food and Drug Administration and the European Medicines Agency for use in cancer patients, and many others are being investigated as standalone therapeutic interventions or combined with conventional treatments in clinical studies. Immunotherapies may be subdivided into "passive" and "active" based on their ability to engage the host immune system against cancer. Since the anticancer activity of most passive immunotherapeutics (including tumor-targeting monoclonal antibodies) also relies on the host immune system, this classification does not properly reflect the complexity of the drug-host-tumor interaction. Alternatively, anticancer immunotherapeutics can be classified according to their antigen specificity. While some immunotherapies specifically target one (or a few) defined tumor-associated antigen(s), others operate in a relatively non-specific manner and boost natural or therapy-elicited anticancer immune responses of unknown and often broad specificity. Here, we propose a critical, integrated classification of anticancer immunotherapies and discuss the clinical relevance of these approaches.

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Classification of current anticancer immunotherapies.

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