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2023
- ISIDORE Id: 10670/1.10a5f5...
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ovarian cancer PARP inhibitors genomic instability GIScar ovarian cancer PARP inhibitors genomic instability GIScarSujets proches
Carcinoma Cancers Malignancy (Cancer) Malignant tumorsCiter ce document
Raphaël Leman et al., « Development of a genomic instability scale for ovarian cancer », Innovations & Thérapeutiques en Oncologie, ID : 10670/1.10a5f5...
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High-grade serous ovarian cancers with deficient homologous DNA repair are particularly sensitive to maintenance therapies including the PARP inhibitor olaparib. This repair deficit generates genomic tumoral “scars.” It is therefore essential to identify patients whose tumors have this repair deficit at initial diagnosis. We have developed a new method, GIScar (Genomic Instability Scar) to detect these scars, which has proven to be highly effective in identifying patients who can benefit from olaparib treatment, with a failure rate of less than 1%. Our data indicate that GIScar may be used in academic and clinical molecular biology laboratories.
