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2022
- ISIDORE Id: 10670/1.121207...
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Therapy IBD (Disease) Inflammatory bowel disease Intestines--Inflammation Pyodermia illnessCiter ce document
Hakima Abid et al., « Pyoderma gangrenosum in chronic inflammatory bowel disease: A study of three cases », Cahiers Santé Médecine Thérapeutique, ID : 10670/1.121207...
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Pyoderma gangrenosum (PG) is an ulcerative form of neutrophilic dermatosis of unknown etiology. It is associated with 2 to 3 percent of inflammatory bowel disease (IBD). Materials and methods: This was a descriptive, monocentric, retrospective study of 3 patients with IBD-associated PG, hospitalized in our hepatogastroenterology department between March 2014 and March 2018. The diagnosis of PG was based on an histological study of cutaneous biopsies. Results: Among the 176 patients monitored for IBD, 3 patients presented with IBD-associated PG (2 women and 1 man) i.e., 1.71%. The mean age of the patients was 44 years. The average duration of disease progression was 10 years. One patient presented with ulcerative colitis (UC) in procto-sigmoiditis, and the other two patients had Crohn’s disease (CD), with a fistulizing and stenosing ileal-colic form in one patient and colic form in the second patient. PG was confirmed by skin biopsy in all our patients. In 2 patients, IBD preceded PG. All our patients received systemic corticosteroid therapy. Maintenance treatment was based on azathioprine alone in 2 cases and infliximab in one 1 case. Complete healing of PG was achieved in all patients. Conclusion: The association of PG and IBD is rare but severe with independent activity. The use of TNF-α antagonists have been reported to be effective for PG associated with IBD.
