Selenium disulfide: a key ingredient to rebalance the scalp microbiome and sebum quality in the management of dandruff
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2023
- handle: 10670/1.1uhhty
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selenium disulfide scalp microbiota Malassezia Staphylococcus Cutibacterium scalp squaleneSujets proches
Therapy Balancing (Physics) Balance (Physics) Balance Selenium disulfide Selenium monosulfideCiter ce document
Cécile Clavaud et al., « Selenium disulfide: a key ingredient to rebalance the scalp microbiome and sebum quality in the management of dandruff », European Journal of Dermatology, ID : 10670/1.1uhhty
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Background: Dandruff is a chronic and relapsing scalp condition characterized by flaky scalp. Environmental and host factors (exposome) may alter the sebaceous gland activity, sebum composition, epidermal barrier function, and scalp microbiome balance, resulting in dandruff. Selenium disulfide (SeS2) improves the clinical signs of dandruff. Objectives: To investigate the mode of action of SeS2 shampoo during treatment and relapse phases. Materials & Methods: Two single-center studies assessed dandruff severity, subjective efficacy perception, microbial balance, microbiota diversity and sebum lipids. Results: SeS2 significantly (p≤0.01) reduced scaling and led to a significant decrease of Malassezia and Staphylococcus spp. counts in both lesional and non-lesional areas, compared to the vehicle at D28 returning to baseline levels at D56. Cutibacterium spp. levels were not different between the SeS2 and the vehicle treatment groups but had significantly increased with SeS2 (p