Pathogen-insect interaction candidate molecules for transmission-blocking control strategies of vector borne diseases
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2018
- ISIDORE Id: 10670/1.4a1fa0...
- 0036-3634
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Salud Pública de México
Mots-clés
Salud Immunity arthropods transmission vector controlSujets proches
Diseases and hygiene Micro-organisms, Pathogenic Disease-causing microorganisms Pathogens Sickness Human beings--Diseases Morbidity Illness Sicknesses IllnessesCiter ce document
Federico Alonso Zumaya et al., « Pathogen-insect interaction candidate molecules for transmission-blocking control strategies of vector borne diseases », Salud Pública de México, ID : 10670/1.4a1fa0...
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Objective. To analyze the current knowledge of pathogen- insect interactions amenable for the design of molecular- based control strategies of vector-borne diseases. Materials and methods. We examined malaria, dengue, and Chagas disease pathogens and insect molecules that participate in interactions during their vectors infection. Results . Pathogen molecules that participate in the insect intestine invasion and induced vector immune molecules are presented, and their inclusion in transmission blocking vaccines (TBV) and in genetically modify insect (GMI) vectors or symbiotic bac - teria are discussed. Conclusion . Disruption of processes by blocking vector-pathogen interactions provides several candidates for molecular control strategies, but TBV and GMI efficacies are still limited and other secondary effects of GMI (improving transmission of other pathogens, affectation of other organisms) should be discarded.
