Prevalence of iron deficiency in patients with non-dialysis-dependent chronic kidney disease: The CARENFER national, multicenter, observational study
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2022
- ISIDORE Id: 10670/1.4ed731...
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Gabriel Choukroun et al., « Prevalence of iron deficiency in patients with non-dialysis-dependent chronic kidney disease: The CARENFER national, multicenter, observational study », Néphrologie & Thérapeutique, ID : 10670/1.4ed731...
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IntroductionIron deficiency is common and associated with worse outcomes in patients with non-dialysis-dependent chronic kidney disease. We performed a national, multicenter, observational, cross-sectional study to assess the prevalence of iron deficiency and current iron deficiency screening practices in this population.Patients and methodsA total of 25 nephrology centers in metropolitan France participated in the study. All adult patients with non-dialysis-dependent chronic kidney disease who met the inclusion criteria (eGFR>15mL/min/1.73m2) and exclusion criteria and gave consent were systematically recruited over a 4-week enrolment period. Investigators were asked to perform a blood test (hemoglobin concentration, serum iron, serum ferritin, and transferrin saturation) and to complete a questionnaire about their iron status monitoring practices. The primary objective was to assess the prevalence of iron deficiency (serum ferritinResultsA total of 1211 patients with non-dialysis-dependent chronic kidney disease were included in the analysis. The overall prevalence of iron deficiency was 47.1%. The rates of absolute iron deficiency and functional iron deficiency and anemia were 13.4% and 17.1%, respectively. Of the 25 participating centers, 12 reported routinely assessing iron status in patients with non-dialysis-dependent chronic kidney disease.ConclusionIn this observational study, a high prevalence of iron deficiency was observed in patients with non-dialysis-dependent chronic kidney disease. Fewer than half of the participating centers reported routinely assessing iron status.
