Effects of gabaa/ώ/cl- agonists on body weight in isolated male mice

Résumé 0

"Numerous studies have demonstrated that GABAA/ω/Cl- receptor agonists mayincrease body weight in grouped rodents. However, there is no evidence in relation to thepossible actions of these drugs under isolation conditions. In this study, we examine theacute and subchronic effects of several doses of benzodiazepines (diazepam, clobazam,bentazepam and midazolam), cyclopyrrolones (zopiclone) and imidazopyridines (zolpidem)on body weight in isolated male mice. All animals were housed individually intransparent plastic cages during 30 days (non-drug period) and weighted weekly. Afterisolation period, drugs were administered acutely or daily for 10 consecutive days andbody weights measured. Results showed that benzodiazepines, cyclopyrrolones and imidazopyridinesdid not vary significantly body weight, as compared with their salinegroups. It is concluded that housing conditions can play a critical role in the modulationof GABAA/ω/Cl- receptor agonists actions on body weight in mice."