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novembre 2019
- ISIDORE Id: 10670/1.61d1a9...
- hal: hal-02263282
- doi: 10.1016/j.envint.2019.105028
- PRODINRA: 482021
- PUBMED: 31382183
- WOS: 000493552400017
HALSHS : archive ouverte en Sciences de l’Homme et de la Société - notices sans texte intégral
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Mots-clés
Adipose tissue Breast cancer Endocrine disrupting chemicals Perfluoroalkyl acid Polychlorinated biphenyls Serum Dioxins Environmental exposure Organochlorine pesticides -bio]/Toxicology/Toxicology and food chain -bio]/Cancer -bio]/Ecology, environment/Health -bio]/Santé publique et épidémiologieSujets proches
Tumor spread Spread of cancer Dissemination of cancer Tumor metastasis Tumor dissemination Metastatic cancer Metastases Cancer--Dissemination Neoplasm metastasis Cancer metastasis Cancer--MetastasisCiter ce document
Meriem Koual et al., « Associations between persistent organic pollutants and risk of breast cancer metastasis », HALSHS : archive ouverte en Sciences de l’Homme et de la Société - notices sans texte intégral, ID : 10.1016/j.envint.2019.105028
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Background: Breast cancer (BC) is a major public health concern with over 2 million new cases diagnosed and over 600,000 deaths in 2018 in women worldwide. When distant metastases are present at diagnosis, the 5-year survival rate is only 26%. Recent studies have suggested that persistent organic pollutants (POPs) that accumulate in adipose tissue (AT) can influence tumor phenotype and stimulate cellular processes important for metastasis such as invasion. We, therefore, tested the hypothesis that POP exposure is associated with BC me-tastasis. Methods: We conducted an exploratory case-control study in which the concentrations of 49 POPs were measured in both AT and serum samples from BC patients, with or without lymph node metastasis, who underwent partial or total mastectomies, lymph node biopsies and sampling of the adipocytic tumor microenvironment. Adjusted, unconditional logistic models were used to study the associations between the POP concentrations and the risk of metastasis and other hallmarks of cancer aggressiveness. Results: 2.3.7.8-TCDD concentrations in AT are positively associated with the risk of metastasis in 43 patients who have BMIs equal or higher than 25 kg/m2 (odds ratio: 4.48 (1.32-20.71)). Furthermore, the concentrations of 2.3.7.8-TCDD and two coplanar PCBs (77&169) in AT also were positively associated with the risk of lymph node metastasis and the tumor size. Conclusion: Our study suggests that 2.3.7.8-TCDD and some PCBs contribute to the development of tumor metastasis and other hallmarks of cancer aggressiveness. While these results should be considered with caution, this is the first study to identify such potential risk factors. Larger longitudinal studies are necessary to confirm our results. Clinical Trial Protocol Record: 2013-A00663-42.
