Memory CD4+ T cells lacking expression of CCR7 promote pro-inflammatory cytokine production in patients with diffuse cutaneous systemic sclerosis
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2019
- ISIDORE Id: 10670/1.698e1f...
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systemic sclerosis memory T cells CD4+ T cells CCR7 SScSujets proches
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Giovanni Almanzar et al., « Memory CD4+ T cells lacking expression of CCR7 promote pro-inflammatory cytokine production in patients with diffuse cutaneous systemic sclerosis », European Journal of Dermatology, ID : 10670/1.698e1f...
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BackgroundSystemic sclerosis (SSc) is a predominantly T-cell-mediated autoimmune disorder with a characteristic sequence of Th1 and Th2 inflammation resulting in fibrosis. The contribution of differentiated memory T-cell subpopulations and methylation of CpG regions of Th1- or Th2-specific transcription factor genes on the inflammatory cytokine signature in SSc is not well understood.
