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11 novembre 2020
- handle: 10670/1.6r02b6
- doi: 10.1007/s11011-014-9573-9
Mots-clés
Hepatic encephalopathy Lactate Brain edema AmmoniaSujets proches
Portal-systemic encephalopathy Encephalopathy, Hepatic Portosystemic encephalopathy Porto-hepatic encephalopathyCiter ce document
Cristina R. Bosoi et al., « Elevated cerebral lactate : implications in the pathogenesis of hepatic encephalopathy », Papyrus : le dépôt institutionnel de l'Université de Montréal, ID : 10.1007/s11011-014-9573-9
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Résumé
Hepatic encephalopathy (HE), a complex neuropsychiatric syndrome, is a frequent complication of liver failure/disease. Increased concentrations of lactate are commonly observed in HE patients, in the systemic circulation, but also in the brain. Traditionally, increased cerebral lactate is considered a marker of energy failure/impairment however alterations in lactate homeostasis may also lead to a rise in brain lactate and result in neuronal dysfunction. The latter may involve the development of brain edema. This review will target the significance of increased cerebral lactate in the pathogenesis of HE.