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- handle: 10670/1.6zsa0e
- hal: hal-03690901
- doi: 10.1016/j.lpm.2018.05.013
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info:eu-repo/semantics/altIdentifier/doi/10.1016/j.lpm.2018.05.013
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Eric Nguyen-Khac et al., « Hépatite alcoolique aiguë sévère », HAL-SHS : histoire, ID : 10.1016/j.lpm.2018.05.013
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All chronic and excessive consumer of alcohol with recent jaundice should be assessed using a Maddrey's score for severe acute alcoholic hepatitis. Corticosteroids are the first line of treatment, associated with an appropriate nutritional support and alcohol abstinence. Corticosteroids plus N-acetylcysteine combination improves short-term survival over corticosteroids alone, and could be proposed as a first line therapy. The response to treatment is evaluated at the 7th day of treatment, with the Lille model ≤ 0.45. Prognostic of non-responders to corticosteroids with Lille model ¿ 0.45 is dramatically low with 23% survival at 6 month. Early liver transplantation in a selected group of patients with non-response to corticosteroids significantly improves 6th month and long-term survival. © 2018 Elsevier Masson SAS