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5 mai 2020
- ISIDORE Id: 10670/1.736c2f...
- doi: 10.1002/acn3.228
Ce document est mis à disposition selon les termes de la Licence Creative Commons Paternité 4.0 International. / This work is licensed under a Creative Commons Attribution 4.0 International License. , http://creativecommons.org/licenses/by/4.0/
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Paradoxical sleep REM sleep Fast wave sleep REMS (Rapid eye movement sleep) Rhombencephalic sleep Animal behavior Habits and behaviorCiter ce document
Anat Mirelman et al., « GBA mutations are associated with Rapid eye movement sleep behavior disorder », Papyrus : le dépôt institutionnel de l'Université de Montréal, ID : 10.1002/acn3.228
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Résumé
Rapid eye movement sleep behavior disorder and GBA mutations are both associated with Parkinson’s disease. The GBA gene was sequenced in idiopathic rapid eye movement sleep behavior disorder patients (n = 265), and compared to controls (n = 2240). Rapid eye movement sleep behavior disorder questionnaire was performed in an independent Parkinson’s disease cohort (n = 120). GBA mutations carriers had an OR of 6.24 (10.2% in patients vs. 1.8% in controls, P < 0.0001) for rapid eye movement sleep behavior disorder, and among Parkinson’s disease patients, the OR for mutation carriers to have probable rapid eye movement sleep behavior disorder was 3.13 (P = 0.039). These results demonstrate that rapid eye movement sleep behavior disorder is associated with GBA mutations, and that combining genetic and prodromal data may assist in identifying individuals susceptible to Parkinson’s disease.
