MRI-based R2* mapping in patients with suspected or known iron overload

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Auteurs
Date

19 juin 2023

Type de document
Périmètre
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Identifiants
Source

Papyrus : le dépôt institutionnel de l'Université de Montréal

Collection

Bibliothèques numériques de l'Université de Montréal

Organisation

Bibliothèque de l'Université de Montréal

Mots-clés Und

Iron overload Hemochromatosis Transfusional hemosiderosis MRI iron quantification R2*

Sujets proches En

Marrow Medulla ossium

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Emre Aslan et al., « MRI-based R2* mapping in patients with suspected or known iron overload », Papyrus : le dépôt institutionnel de l'Université de Montréal, ID : 10.1007/s00261-020-02912-w

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Purpose R2* relaxometry is a quantitative method for assessment of iron overload. The purpose is to analyze the cross-sectional relationships between R2* in organs across patients with primary and secondary iron overload. Secondary analyses were conducted to analyze R2* according to treatment regimen. Methods This is a retrospective, cross-sectional, institutional review board-approved study of eighty-one adult patients with known or suspected iron overload. R2* was measured by segmenting the liver, spleen, bone marrow, pancreas, renal cortex, renal medulla, and myocardium using breath-hold multi-echo gradient-recalled echo imaging at 1.5 T. Phlebotomy, transfusion, and chelation therapy were documented. Analyses included correlation, Kruskal–Wallis, and post hoc Dunn tests. p 

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