Pre-European contact leprosy in the Americas and its current persistence

Ce document est lié à :
info:eu-repo/grantAgreement//948800/EU/A microbial perspective of major historical events in the Southern Cone of the Americas/PaleoMetAmerica

Ce document est lié à :
info:eu-repo/grantAgreement//101071707/EU/Horse Power: Interactions between China, Mongolia and the steppe 2000-0 BCE/ERC-2022-SYG

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Centre pour la communication scientifique directe

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http://creativecommons.org/licenses/by-nc-nd/ , info:eu-repo/semantics/OpenAccess

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-bio]/Human health and pathology/Infectious diseases

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Americas New World

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Maria Lopopolo et al., « Pre-European contact leprosy in the Americas and its current persistence », HAL SHS (Sciences de l’Homme et de la Société), ID : 10.1126/science.adu7144

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Leprosy, primarily caused by Mycobacterium leprae , is considered a disease introduced into the Americas during European colonization. However, the recent discovery of a second pathogen causing leprosy, M. lepromatosis , mainly found in the Americas, challenges this view. Here, we show that M. lepromatosis infected humans in the Americas before European contact. By screening 389 ancient and 408 contemporary samples, we have expanded the genetic data available for the species. Phylogenetic analyses revealed distinct human-infecting clades of M. lepromatosis , with one dominating North America since colonial times. The presence of millennia-old strains in North and South America indicates M. lepromatosis may have been widespread during the Late Holocene, demonstrating M. lepromatosis leprosy has a long-standing history in the Americas before European arrival.

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Pre-European contact leprosy in the Americas and its current persistence

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