Fiche du document
2023
- handle: 10670/1.7kbdby
Cairn
Mots-clés
Flavivirus alcaloïdes lycorine Amaryllidaceae VIH-1 coronavirus Alphavirus Flavivirus Amaryllidaceae alkaloids lycorine HIV-1 coronavirus AlphavirusSujets proches
AlcaloidsCiter ce document
Marie-Pierre Girard et al., « Le pouvoir antiviral des alcaloïdes de végétaux contre les virus à ARN », Virologie, ID : 10670/1.7kbdby
Métriques
Partage / Export
Résumé
RNA viruses are the most common class of pathogens responsible for the emergence of new human diseases, with two to three newly identified viruses annually. The recent 2019 coronavirus disease pandemic (Covid-19) underscores the importance of discovering new and effective antiviral agents. Alkaloids are a class of heterocyclic organic molecules bearing one or more nitrogen atoms and exhibiting a wide variety of structures. Several plant alkaloids are known for their extensive therapeutic properties. The objective of this review is to highlight the antiviral potential of alkaloids from Amaryllidaceae and from other types of plants against several families of RNA viruses, such as Flaviviruses, coronaviruses, Alphaviruses, Alphainfluenzaviruses and also against human immunodeficiency virus type 1 (HIV-1). Alkaloids act against viruses using several strategies and target both viral and cellular proteins. These molecules are bioactive agents that offer attractive prospects in the search for new antiviral drugs.