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2023
- handle: 10670/1.7to0k2
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epidermal nevus nevus depigmentosus melanosome epidermal differentiation keratin filaggrinSujets proches
Moles (Dermatology) Naevus Nevus NevusCiter ce document
Ken Natsuga et al., « Congenital nevi with hypomelanosis and fine scales », European Journal of Dermatology, ID : 10670/1.7to0k2
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Background: Nevus is a hamartoma or malformation of one or more skin components, resulting in aberrant differentiation of the cell lineage(s) mostly during developmental stages. Although multiple lineages may be involved in a nevus, the combination of melanocyte and keratinocyte abnormalities has been rarely discussed. Objectives. To present two cases of congenital nevi with hypomelanosis and superficial fine scales. Materials & Methods: Skin specimens of the patients were analysed by immunohistochemistry and electron microscopy. Results: Morphological and immunohistochemical studies indicated aberrant epidermal differentiation in the lesional skin specimens. Electron microscopy showed defective melanosome maturation in the melanocytes of the nevi samples. Conclusion: These results demonstrate that both epidermal and melanocytic lineages can concomitantly contribute to the formation of a nevus lesion.