Fiche du document
11 novembre 2020
- handle: 10670/1.8fl47z
- doi: 10.1007/s00134-003-2141-0
Mots-clés
Albumin dialysis Charcoal Adsorption Midazolam FentanylSujets proches
MarsCiter ce document
Sambit Sen et al., « Albumin dialysis : a new therapeutic strategy for intoxication from protein-bound drugs », Papyrus : le dépôt institutionnel de l'Université de Montréal, ID : 10.1007/s00134-003-2141-0
Métriques
Partage / Export
Résumé
Objective: Although water-soluble drugs can be removed by haemofiltration/haemodialysis, morbidity and mortality from intoxication with protein-bound drugs remains high. The present study investigates whether albumin dialysis in the form of the Molecular Adsorbents Recirculating System (MARS) is effective in removal of protein-bound drugs. Design: Prospective animal study. Setting: Surgical research laboratory in a university hospital. Subjects: Seven female Norwegian Landrace pigs. Intervention: We studied whether midazolam (97% albuminbound) and fentanyl (85% alpha-1- acid glycoprotein-bound), administered as anaesthetics to pigs with induced acute liver failure, could be removed by MARS dialysis lasting for 4 h. Measurements: After 4 h of dialysis, total and free anaesthetic concentrations were measured in the blood and dialysate from different segments of the MARS circuit. Main results: Midazolam: total plasma concentrations fell by 47.1€2.1% (in 4 h) across the MARS filter (p