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20 avril 2020
- handle: 10670/1.b9mlph
- hal: hal-02558255
- doi: 10.1002/bies.201900255
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info:eu-repo/semantics/altIdentifier/doi/10.1002/bies.201900255
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info:eu-repo/grantAgreement//637647/EU/Immunity, DEvelopment and Microbiota: Understanding the Continuous Construction of Biological Identity/IDEM
info:eu-repo/semantics/OpenAccess
Mots-clés
microbiome structure function research practice sequence data taxonomic composition -bio]/Biochemistry, Molecular Biology/Molecular biology -bio]/Biochemistry, Molecular Biology/Molecular Networks [q-bio.MN]Sujets proches
Natural science Sciences Science of science Scientific research Science research Science--ResearchCiter ce document
Gregor P. Greslehner, « Microbiome structure and function: A new framework for interpreting data », HAL-SHS : philosophie, ID : 10.1002/bies.201900255
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Résumé
I suggest a distinction between different notions of ‘structure’ and ‘function’ for interpreting the overwhelming amount of data on microbiome structure and function: sequence data, biochemical agents, interaction networks, taxonomic communities, and their dynamics can be linked to potential or actual biochemical activities, causal roles, and selected effects, respectively. This conceptual clarification has important methodologicalconsequences for how to interpret existing data and approach open questions in contemporary microbiome research practice. In particular, the field will have to start thinking about notions of function more directly.