Modification of aflatoxin B1 and ochratoxin A toxicokinetics in rats administered a yeast cell wall preparation
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28 juin 2010
- handle: 10670/1.bgv8ta
- hal: hal-00604043
- doi: 10.1080/19440041003801174
- PRODINRA: 39759
- WOS: 000279331700013
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info:eu-repo/semantics/altIdentifier/doi/10.1080/19440041003801174
info:eu-repo/semantics/OpenAccess
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Stéphane Firmin et al., « Modification of aflatoxin B1 and ochratoxin A toxicokinetics in rats administered a yeast cell wall preparation », HALSHS : archive ouverte en Sciences de l’Homme et de la Société, ID : 10.1080/19440041003801174
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Résumé
The cell wall of Saccharomyces cerevisiae can bind mycotoxins in vitro but there is scarce information on whether this property decreases the absorption of mycotoxins in vivo. The effect of a yeast cell wall preparation (YCW) on toxicokinetics and balance excretion (urine and faeces) of aflatoxin B1 (AFB1) and ochratoxin A (OTA) was tested in rats after oral administration of each toxin. The 3H-labelled mycotoxins were used at low doses. Co-administration of YCW with AFB1 decreased the extent but not the rate of absorption. Concurrently, radioactivity excreted in faeces increased by up to 55% when compared to controls, whilst the excretion in urine decreased (p < 0.05). The effect of YCW on OTA was less marked, although it increased radioactivity excretion in faeces (up to 16%; p < 0.05) it did not result in changes in urine and toxicokinetic parameters. The in vivo effect is in agreement with the reported in vitro binding ability for these toxins (AFB1 > OTA). In conclusion, these results indicate that YCW could be used to protect monogastric animals against exposure to low dietary levels of selected mycotoxins.