Mechanism of insulin resistance in a rat model of kidney disease and the risk of developing type 2 diabetes
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17 janvier 2023
- handle: 10670/1.bu98ya
- doi: 10.1371/journal.pone.0176650
Ce document est mis à disposition selon les termes de la Licence Creative Commons Paternité 4.0 International. / This work is licensed under a Creative Commons Attribution 4.0 International License. , https://creativecommons.org/licenses/by/4.0/
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François Dion et al., « Mechanism of insulin resistance in a rat model of kidney disease and the risk of developing type 2 diabetes », Papyrus : le dépôt institutionnel de l'Université de Montréal, ID : 10.1371/journal.pone.0176650
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Chronic kidney disease is associated with homeostatic imbalances such as insulin resistance. However, the underlying mechanisms leading to these imbalances and whether they promote the development of type 2 diabetes is unknown. The effect of chronic kidney disease on insulin resistance was studied on two different rat strains. First, in a 5/6th nephrectomised Sprague-Dawley rat model of chronic kidney disease, we observed a correlation between the severity of chronic kidney disease and hyperglycemia as evaluated by serum fructosamine levels (p