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2016
- handle: 10670/1.cbh0ap
- Sanchez-Ferras, Oraly; Bernas, Guillaume; Farnos, Omar; Touré, Aboubacrine M.; Souchkova, Ouliana et Pilon, Nicolas (2016). « A direct role for murine Cdx proteins in the trunk neural crest gene regulatory network ». Development, 143(8), pp. 1363-1374.
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http://archipel.uqam.ca/11980/
Ce document est lié à :
http://dx.doi.org/10.1242/dev.132159
Ce document est lié à :
doi:10.1242/dev.132159
Mots-clés
Cdx Neural crest Gene regulatory network Melanocyte Peripheral nervous system Enteric nervous systemSujets proches
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Oraly Sanchez-Ferras et al., « A direct role for murine Cdx proteins in the trunk neural crest gene regulatory network », UQAM Archipel : articles scientifiques, ID : 10670/1.cbh0ap
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Numerous studies in chordates and arthropods currently indicate that Cdx proteins have a major ancestral role in the organization of posthead tissues. In urochordate embryos, Cdx loss-of-function has been shown to impair axial elongation, neural tube (NT) closure and pigment cell development. Intriguingly, in contrast to axial elongation and NT closure, a Cdx role in neural crest (NC)-derived melanocyte/ pigment cell development has not been reported in any other chordate species. To address this, we generated a new conditional pan-Cdx functional knockdown mouse model that circumvents Cdx functional redundancy as well as the early embryonic lethality of Cdx mutants. Through directed inhibition in the neuroectoderm, we provide in vivo evidence that murine Cdx proteins impact melanocyte and enteric nervous system development by, at least in part, directly controlling the expression of the key early regulators of NC ontogenesis Pax3, Msx1 and Foxd3. Our work thus reveals a novel role for Cdx proteins at the top of the trunk NC gene regulatory network in the mouse, which appears to have been inherited from their ancestral ortholog.