Trem2-expressing multinucleated giant macrophages are a biomarker of good prognosis in head and neck squamous cell carcinoma
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16 septembre 2024
- ISIDORE Id: 10670/1.cd0e6e...
- inserm-04729854
- doi: 10.1158/2159-8290.CD-24-0018
- PUBMED: 39270324
- PUBMEDCENTRAL: PMC11609822
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Mots-clés
TREM2 CHIT1 macrophages multinucleated giant cells squamous cell carcinoma keratin head & amp neck cancer biomarker prognosis -bio]/CancerSujets proches
Prognosis of diseases Medical prognosis Mononuclear phagocytes HistiocytesCiter ce document
Grégoire Gessain et al., « Trem2-expressing multinucleated giant macrophages are a biomarker of good prognosis in head and neck squamous cell carcinoma », HAL SHS (Sciences de l’Homme et de la Société), ID : 10.1158/2159-8290.CD-24-0018
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Patients with head and neck squamous cell carcinomas (HNSCC) often havepoor outcomes due to suboptimal risk management and treatment strategies;yet integrating novel prognostic biomarkers into clinical practice is challenging. Here, we reportthe presence of multinucleated giant cells (MGC)—a type of macrophages—in tumors from patientswith HNSCC, which are associated with a favorable prognosis in treatment-naive and preoperativechemotherapy–treated patients. Importantly, MGC density increased in tumors following preoperative therapy, suggesting a role of these cells in the antitumoral response. To enable clinical translationof MGC density as a prognostic marker, we developed a deep-learning model to automate its quantification on routinely stained pathological whole slide images. Finally, we used spatial transcriptomicand proteomic approaches to describe the MGC-related tumor microenvironment and observed anincrease in central memory CD4 T cells. We defined an MGC-specific signature resembling to TREM2-expressing mononuclear tumor-associated macrophages, which colocalized in keratin tumor niches.
