Overweight is associated to a better prognosis in metastatic colorectal cancer: A pooled analysis of FFCD trials
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26 mai 2018
- ISIDORE Id: 10670/1.dd95cc...
- hal: hal-04494820
- doi: 10.1016/j.ejca.2018.03.031
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info:eu-repo/semantics/altIdentifier/doi/10.1016/j.ejca.2018.03.031
http://creativecommons.org/licenses/by-nc-nd/ , info:eu-repo/semantics/OpenAccess
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Thomas Aparicio et al., « Overweight is associated to a better prognosis in metastatic colorectal cancer: A pooled analysis of FFCD trials », HAL SHS (Sciences de l’Homme et de la Société), ID : 10.1016/j.ejca.2018.03.031
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Background: Previous studies showed that high and low body mass index (BMI) was associated with worse prognosis in early-stage colorectal cancer (CRC), and low BMI was associated with worse prognosis in metastatic CRC (mCRC). We aimed to assess efficacy outcomes according to BMI.Patients and methods: A pooled analysis of individual data from 2085 patients enrolled in eight FFCD first-line mCRC trials from 1991 to 2013 was performed. Comparisons were made according to the BMI cut-off: Obese (BMI ≥30), overweight patients (BMI ≥ 25), normal BMI patients (BMI: 18.5-24) and thin patients (BMI
