Fiche du document
1 mars 2000
- handle: 10670/1.dju7bo
- hal: hal-03679812
- PUBMED: 11004971
Ce document est lié à :
info:eu-repo/semantics/altIdentifier/pmid/11004971
Mots-clés
MESH: Adult MESH: Aged MESH: Myocardial Ischemia MESH: Prospective Studies MESH: Risk Factors MESH: Diabetes Mellitus, Type 2 MESH: Female MESH: Heart Diseases MESH: Heart Rate MESH: Humans MESH: Incidence MESH: Male MESH: Middle AgedSujets proches
Abnormities and deformities Deformities Cycle, Cardiac Cardiac cycle Heart rate Heart cycle Diabetes--Patients Older persons Older adults Seniors (Older people) Elderly people Old people Senior citizens Aging people Aged Plants--Deformities Deformities in plants Abnormalities in plants Abnormalities (Plants) Botany--Teratology Abnormalities Malformations in animals Abnormalities (Animals) Animals--Malformations Animal abnormalities Animal malformations Zoology--Teratology Abnormalities in animals Deformities in animals Animals--Deformities Animal deformities Abnormalities Defects, Birth Malformations, Congenital Congenital anomalies Developmental abnormalities Congenital abnormalities Anomalies, Congenital Human abnormalities Deformities Birth defects AbnormalitiesCiter ce document
B Barthélemy et al., « [Cardiac abnormalities in a prospective series of 40 patients with type 2 diabetes]. », HALSHS : archive ouverte en Sciences de l’Homme et de la Société, ID : 10670/1.dju7bo
Métriques
Partage / Export
Résumé
Cardiovascular mortality, the principal cause of early death in diabetics, is multifactorial. A prospective study was undertaken to analyse the different factors of excess cardiac complications in 40 patients with type 2 diabetes, whatever the symptomatology, by making an inventory of the cardiac abnormalities (systolic and diastolic left ventricular function, left ventricular hypertrophy, abnormalities of myocardial perfusion, heart rate variability and arrhythmias). Patients underwent 24 hour Holter monitoring, high amplification signal averaged electrocardiography, echocardiography, Thallium scintigraphy with a dipyridamole test followed by coronary angiography when positive. Patients were aged 60 +/- 8 years, diabetics for 11.8 +/- 6.8 years, and had associated cardiovascular risk factors: 85% were obese, 75% were hypertensive, 62.5% had hypercholesterolaemia and 60% were smokers. The HbA1C was 9.2 +/- 19%. An increased left ventricular mass was observed in 34.2% of patients. The left ventricular ejection fraction was normal (59.1 +/- 6.8%); 69.7% of patients had left ventricular diastolic dysfunction. Reduced heart rate variability was observed in 51.8% of cases. Late ventricular potentials were recorded on high amplification signal averaging in 39.5% of patients; 25.6% had significant ventricular extrasystoles and 52.2% had atrial extrasystoles. Twelve patients (45%) underwent Thallium myocardial scintigraphy with a positive dipyridamole test, 8 of whom had coronary lesions on angiography. The excess cardiac complications of diabetes is mainly due to ischaemic heart disease aggravated by autonomic neuropathy, left ventricular diastolic dysfunction, arrhythmias and left ventricular hypertrophy. In future, larger series are required to demonstrate that this detection can guide therapeutic intervention and reduce cardiac morbidity and mortality of diabetics.