APOE4 is associated with elevated blood lipids and lower levels of innate immune biomarkers in a tropical Amerindian subsistence population
Fiche du document
29 septembre 2021
- handle: 10670/1.dutwbn
- hal: hal-03364139
- doi: 10.7554/eLife.68231
Ce document est lié à :
info:eu-repo/semantics/altIdentifier/doi/10.7554/eLife.68231
info:eu-repo/semantics/OpenAccess
Sujets proches
Populations, Human Human populations Population growth Human population Inflammatory process Cholesterin Serum lipids Plasma lipids Biologic markers Biological markers Biomarkers Markers, Biochemical Demography DemographicsCiter ce document
Angela Garcia et al., « APOE4 is associated with elevated blood lipids and lower levels of innate immune biomarkers in a tropical Amerindian subsistence population », HALSHS : archive ouverte en Sciences de l’Homme et de la Société, ID : 10.7554/eLife.68231
Métriques
Partage / Export
Résumé
In post-industrial settings, apolipoprotein E4 (APOE4) is associated with increased cardiovascular and neurological disease risk. However, the majority of human evolutionary history occurred in environments with higher pathogenic diversity and low cardiovascular risk. We hypothesize that in high-pathogen and energy-limited contexts, the APOE4 allele confers benefits by reducing innate inflammation when uninfected, while maintaining higher lipid levels that buffer costs of immune activation during infection. Among Tsimane forager-farmers of Bolivia (N = 1266, 50% female), APOE4 is associated with 30% lower C-reactive protein, and higher total cholesterol and oxidized LDL. Blood lipids were either not associated, or negatively associated with inflammatory biomarkers, except for associations of oxidized LDL and inflammation which were limited to obese adults. Further, APOE4 carriers maintain higher levels of total and LDL cholesterol at low body mass indices (BMIs). These results suggest that the relationship between APOE4 and lipids may be beneficial for pathogen-driven immune responses and unlikely to increase cardiovascular risk in an active subsistence population.