Renal dysfunction independently predicts muscle mass loss in patients following liver transplantation
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10 mai 2022
- handle: 10670/1.e4xlgx
- doi: 10.3138/canlivj-2021-0042
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Muscle Musculature Myodynamics MyologyCiter ce document
Mimosa Nguyen et al., « Renal dysfunction independently predicts muscle mass loss in patients following liver transplantation », Papyrus : le dépôt institutionnel de l'Université de Montréal, ID : 10.3138/canlivj-2021-0042
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Résumé
Liver transplantation (LT) is the only curative treatment for cirrhosis. However, the presence of complications can impact outcomes following LT. Sarcopenia, or muscle mass loss, is highly prevalent in patients with cirrhosis and is associated with longer hospitalization stays and a higher infection rate post-surgery. We aimed to identify patients at higher risk of early sarcopenia post-LT. METHODS: This retrospective study included 79 cirrhotic patients who underwent LT. Muscle mass was evaluated using the third lumbar spine vertebra skeletal muscle mass index (SMI) and sarcopenia was defined using established cut-off values. Computerized tomography (CT) scans performed within six-month peri-operative period (three months pre- and post-LT) were included in the study. Complications and comorbidities were collected and correlated to SMI post-LT and predictive models for SMI post-LT were constructed. RESULTS: The overall prevalence of sarcopenia was 46% and 62% before and after LT, respectively. Newly developed sarcopenia was found in 42% of patients. Post-LT sarcopenia was associated with longer hospital stays (54±37 vs 29±10 days, p = 0.002), higher number of infection (3±1 vs 1±2, p = 0.027), and greater number of complications (5±2 vs 3±2, p