Fiche du document
2022
- ISIDORE Id: 10670/1.f1025d...
Cairn
Sujets proches
CaseCiter ce document
Pauline Masson et al., « Waldenström macroglobulinemia highlighted by turbidity interference: A case report », Annales de Biologie Clinique, ID : 10670/1.f1025d...
Métriques
Partage / Export
Résumé
A 65-year-old female was admitted to the emergency department after a fall. Upon admission, a blood sample was taken for routine laboratory tests. Blood glucose measurement using the hexokinase method was made impossible due to a high lipemia index measured by the instrument, despite a clear plasma specimen. It is well known that hemolysis, icterus, and lipemia interferences disrupt spectrophotometric quantifications. However, in this case, the absence of lipemia was confirmed by a plasma triglyceride measurement in the normal reference range. Protein electrophoresis along with an immunofixation test were carried out to characterize a monoclonal gammopathy, since the presence of a monoclonal gammopathy in very high concentrations generates turbidity and interferes with spectrophotometric assays. A gamma peak evoking a monoclonal gammopathy was found on the serum electrophoresis and the immunofixation was positive for a monoclonal IgM kappa. A myelogram showed plasmocytes, lymphoplasmacytic cells, and mast cell infiltration, which led to the diagnosis of Waldenström macroglobulinemia. Based on this case, we propose a course of action to be taken in the case of a high lipemia index and clear plasma.
