Efficacy of the ketogenic diet on ACTH- or corticosteroid-resistant infantile spasm: a multicentre prospective control study

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Auteurs
Date

2021

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Périmètre
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Epileptic Disorders

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Cairn.info

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Cairn

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Cairn

Mots-clés En

efficacy genomics infantile spasms ketogenic diet

Sujets proches En

Hypsarrhythmia Infantile myoclonic epilepsy Myoclonic epilepsy, Infantile Infantile spasms Neonatal seizures West's syndrome

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Jie Zhang et al., « Efficacy of the ketogenic diet on ACTH- or corticosteroid-resistant infantile spasm: a multicentre prospective control study », Epileptic Disorders, ID : 10670/1.f7726b...

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Objective. To determine the efficacy of ketogenic diet (KD) therapy on adrenocorticotropic hormone- (ACTH) or corticosteroid-resistant infantile spasm (IS), and identify relevant associated factors.Methods. A prospective controlled study was undertaken at 10 tertiary children's medical centres in mainland China. Participants were non-randomly assigned to KD therapy or control (adjustment of antiepileptic drugs). The primary outcome was the reduction in spasms and remission of hypsarrhythmia at the 16th week, divided into Grade I (spasm-free for at least one week with hypsarrhythmia remission), Grade II (≥50% spasm reduction and/or hypsarrhythmia remission) and Grade III (

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