Management of iron deficiency in chronic kidney disease: Focus review and proposed algorithm

Résumé 0

Iron deficiency is very common in chronic kidney disease, even before the dialysis stage. It is an independent factor of morbidity and mortality in patients with non-dialysis-dependent chronic kidney disease. In patients with chronic kidney disease, iron deficiency is defined by a transferrin saturation 100 μg/L). Despite this, iron deficiency is usually not investigated: over 60% of nephrologists do not assess iron status at least once a year. Iron deficiency is also rarely treated, with only 12% of patients prescribed oral or intravenous iron. Early detection and treatment are fundamental and should be done routinely. To help improve the management of iron deficiency among patients with non-dialysis-dependent chronic kidney disease, we propose an algorithm that takes into account current recommendations and the most recent data from the literature. The initial blood tests should measure hemoglobin concentration, transferrin saturation, and serum ferritin. A transferrin saturation