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This book examines a new field of nature-mimicked nanotechnology and chemical manipulation, focusing on the mechanisms, principles, and manufacturing of self-cleaning surfaces and describing how these materials can be created for scalable production. Self-cleaning ability on the topmost surfaces of materials increases a product’s value for applications in microfluidics, lap-on-chip, microreactors, air purification, and more. An easy way to obtain self-cleaning properties is by creating superhydrophobic surfaces so water droplets can roll down, picking up dirt particles on the way. This book provides a comprehensive overview of self-cleaning properties in nanotechnology. It includes six chapters that address such topics as the fabrication and applications of biomimetic superhydrophobic materials, self-cleaning surfaces of different plants, self-cleaning polyurethane surfaces, self-cleaning approaches using plasma, and laser technology for superhydrophobic self-cleaning applications.