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23 août 2011
- handle: 10670/1.fpljjc
- Boc, A. et Makarenkov, V. (2011). « Towards an accurate identification of mosaic genes and partial horizontal gene transfers ». Nucleic Acids Research, 39(21), e144.
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http://archipel.uqam.ca/7829/
Ce document est lié à :
http://dx.doi.org/10.1093/nar/gkr735
Ce document est lié à :
doi:10.1093/nar/gkr735
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mosaic genes gene transfersSujets proches
Units of inheritance Units of heredityCiter ce document
A. Boc et al., « Towards an accurate identification of mosaic genes and partial horizontal gene transfers », UQAM Archipel : articles scientifiques, ID : 10670/1.fpljjc
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Résumé
Many bacteria and viruses adapt to varying environmental conditions through the acquisition of mosaic genes. A mosaic gene is composed of alternating sequence polymorphisms either belonging to the host original allele or derived from the integrated donor DNA. Often, the integrated sequence contains a selectable genetic marker (e.g. marker allowing for antibiotic resistance). An effective identification of mosaic genes and detection of corresponding partial horizontal gene transfers (HGTs) are among the most important challenges posed by evolutionary biology. We developed a method for detecting partial HGT events and related intragenic recombination giving rise to the formation of mosaic genes. A bootstrap procedure incorporated in our method is used to assess the support of each predicted partial gene transfer. The proposed method can be also applied to confirm or discard complete (i.e. traditional) horizontal gene transfers detected by any HGT inferring method. While working on a fullgenome scale, the new method can be used to assess the level of mosaicism in the considered genomes as well as the rates of complete and partial HGT underlying their evolution.