[Conduction defects as the presenting feature of sarcoidosis or observed during the course of the disease: regression with corticoid steroid therapy].
Fiche du document
1 juin 2003
- handle: 10670/1.g5wwnz
- hal: hal-03679638
- PUBMED: 12868351
Ce document est lié à :
info:eu-repo/semantics/altIdentifier/pmid/12868351
Mots-clés
MESH: Adrenal Cortex Hormones MESH: Adult MESH: Magnetic Resonance Imaging MESH: Sarcoidosis MESH: Treatment Outcome MESH: Cardiomyopathies MESH: Diagnosis, Differential MESH: Echocardiography MESH: Electrocardiography MESH: Electrocardiography, Ambulatory MESH: Female MESH: Heart Block MESH: HumansSujets proches
Boeck's sarcoid Schaumann's disease Granuloma benignum Lymphogranulomatosis benigna Besnier-Boeck diseaseCiter ce document
M Berhouet et al., « [Conduction defects as the presenting feature of sarcoidosis or observed during the course of the disease: regression with corticoid steroid therapy]. », HALSHS : archive ouverte en Sciences de l’Homme et de la Société, ID : 10670/1.g5wwnz
Métriques
Partage / Export
Résumé
Cardiac sarcoidosis is often unrecognised because of the absence of specific clinical and electrical signs. The consequences are serious, the main risk being sudden death due to conduction defects (24 to 31% of cases) or ventricular arrhythmias. Any conduction defect without an obvious cause in a young patient should suggest a possible diagnosis of sarcoidosis. The confirmation is histological when giant cell non-caseuting epithelioid granuloma is demonstrated but myocardial biopsies are only positive in 20% of cases. Therefore, biopsy of accessible organs such as salivary glands is recommended. Diagnostic strategy consists in searching for signs of systemic sarcoidosis, and, when the diagnosis has been established, perform a complete work-up with echocardiography, dipyridamole myocardial scintigraphy, cardiac MRI and 24 hour ambulatory ECG recordings (Holter). The only proven treatment is steroid therapy with occasional spectacular observations of reversibility of arrhythmias or conduction defects.