Chronic kidney disease consecutive to chemotherapy for chondroblastic osteosarcoma: A report on 6 pediatric cases
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2021
- handle: 10670/1.gje383
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Chondroblastic osteosarcoma Chronic kidney disease Glomerular toxicity Ifosfamide Nephrotoxicity Pediatric tumorSujets proches
Osteoid sarcoma Osteogenic sarcoma Bone sarcoma Osteolytic sarcoma illnessCiter ce document
Alice Paul et al., « Chronic kidney disease consecutive to chemotherapy for chondroblastic osteosarcoma: A report on 6 pediatric cases », Néphrologie & Thérapeutique, ID : 10670/1.gje383
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Background. – The management of osteosarcoma in children and adolescents is based on polychemotherapy including several nephrotoxic drugs (e.g. ifosfamide, methotrexate, and cisplatinum). Chronic renal toxicity is a frequent complication but stage 5 chronic kidney disease requiring dialysis is rare. We report here a series of six pediatric patients with osteosarcoma displaying chronic kidney disease after chemotherapy. Case-diagnosis/treatment. – We retrospectively reviewed the medical charts, mainly for clinical history, timing between chemotherapy and development of tubulopathy and CKD, type of therapies and global evolution (chronic dialysis and further renal transplantation, n = 2; death, n = 1). Notably, all patients suffered from chondroblastic osteosarcoma. Conclusions. – Advanced chronic kidney disease can be a complication of osteosarcoma management that could more frequently lead to dialysis and further transplantation. It would be interesting to identify specific risk factors of such renal toxicity. The chondroblastic sub-type may be associated with such susceptibility, but this needs to be confirmed.