Selenium Disulfide-based shampoo applied for 4 weeks significantly improves dandruff and seborrheic dermatitis
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2023
- handle: 10670/1.hyez7e
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selenium disulfide dandruff seborrheic dermatitisSujets proches
Dermatitis Skin--Redness Redness of the skinCiter ce document
Gabriela Turcu et al., « Selenium Disulfide-based shampoo applied for 4 weeks significantly improves dandruff and seborrheic dermatitis », European Journal of Dermatology, ID : 10670/1.hyez7e
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Seborrheic Dermatitis (SD) is a chronic and relapsing inflammatory condition accompanied by erythema, flaking and itching. Dandruff is a milder form of SD. Selenium disulfide (SeS2) is beneficial in both conditions. Objectives: to assess the efficacy of SeS2-based shampoo in dandruff/SD. Materials & Methods: an international, multicenter, observational study was conducted in 1407 adult subjects. SeS2- based shampoo was used 2 to 3 times per week for 4 weeks. Clinical efficacy criteria included improvement of hair, flaking, erythema and irritation on a scale from 0 to 5; investigator satisfaction was assessed at month 3 from 0 to 10. The subjects rated the impact of their hair problem (0 to 5), efficacy and satisfaction with SeS2-based shampoo at month 3. Tolerance was assessed throughout the study. Results: At baseline, 68.2% had a flake severity score of 3-5, 49.9% an erythema severity score of 3-5, and 46.2% an irritation severity score of 3-5; 28.2% were bothered and 41.5% were very bothered. At study end, SD/D had at least clearly improved in 89.6% of subjects. All clinical signs had significantly (p