Disentangling the reasons why older adults do not readily participate in cancer trials: a socio-epidemiological mixed methods approach
Fiche du document
1 février 2024
- handle: 10670/1.j1tufl
- hal: hal-04604592
- doi: 10.1093/ageing/afae007
- PUBMED: 38346934
- PUBMEDCENTRAL: PMC10861365
Ce document est lié à :
info:eu-repo/semantics/altIdentifier/doi/10.1093/ageing/afae007
Ce document est lié à :
info:eu-repo/semantics/altIdentifier/pmid/38346934
info:eu-repo/semantics/OpenAccess
Mots-clés
cancer trial inclusion non-invitation older people participation refusal to participate -bio]/Cancer -bio]/Human health and pathology/Geriatry and gerontology -bio]/Santé publique et épidémiologieSujets proches
Carcinoma Cancers Malignancy (Cancer) Malignant tumorsCiter ce document
Meoïn Hagège et al., « Disentangling the reasons why older adults do not readily participate in cancer trials: a socio-epidemiological mixed methods approach », HAL-SHS : sociologie, ID : 10.1093/ageing/afae007
Métriques
Partage / Export
Résumé
Background Few studies of the under-representation of older adults in cancer clinical trials (CTs) have encompassed the entire pathway from a trial being available in a cancer centre to the patient’s invitation to participate and then agreement or refusal to participate. Objectives The study’s primary objective was to evaluate CT non-invitation and refusal rates. The secondary objectives were to identify factors associated with non-invitation and refusal and to assess experiences of CT participation from the patients’ and professionals’ perspectives. Methods Here, we used mixed methods and a socio-epidemiological approach to analyse reasons for the non-participation of eligible older patients with a solid cancer in cancer CTs in France. Results We found that non-invitation and low CT participation are mainly related to the patients’ sociodemographic characteristics and living conditions (such as social isolation, being single, divorced or widowed, not having children and the absence of close family members) and the healthcare professionals’ perceptions of insufficient informal support or a high homecare requirement. Conclusion Our results suggest that efforts to increase fair inclusion and the participation of older adults in CTs should target the physician–patient relationship, the medical profession and hospital funding, rather than the patient alone.